Publications
and Posters

Two men at a table with laptop and notepad

PUBLICATIONS (16 of 40)

 A Full List of Publications and Presentations Is Available upon Request 

  1.  Dubiel EA, Myler H, Arnold ME, Bennett P, Gatz J, Groeber E, Gupta S, Kane C, Li F, Mylott W, Noah C, O'Dell M, Tewalt E, Warrino D, Vick A. Biological Matrix Supply Chain Shortages: More Matrices Are Now Rare-the Case for Surrogate Matrices. AAPS J. 2022; 24(2):42. 

  2. Li F, Xing G, Cousineau C, Clemens S, Mofikoya M, Kim MY, Zhang JY, Zhang Y, Raha N. Development and validation of a HILIC-MS/MS method for the quantitation of fructose in human urine in support of clinical programs. J Pharm Biomed Anal. 2022, 208:114462.   

  3. Feng Yin; Yonghua Ling; Jason Martin; Rohini Narayanaswamy; Lisa Mclntosh; Fumin Li; Guowen Liu.  Quantitation of Uridine and L-Dihydroorotic Acid in Human Plasma by LC-MS/MS Using a Surrogate Matrix Approach.  J. Pharm. Biomed. Anal., 2021, 192:113669.   

  4. Yin F, Ling Y, Keller J, Kraus D, Narayanaswamy R, Mangus H, Li Fumin, Yang H, Liu G.Yin F. Quantitation of 2-hydroxyglutarate in human plasma via LC-MS/MS using a surrogate analyte approach. Bioanalysis. 2020, 12(16), 1149 - 1159. 

  5. Ping Jiang, Jie Ding, and Fumin Li Development of an Efficient LC-MS Peptide Mapping Method Using Accelerated Sample Preparation for Monoclonal Antibodies. J Chromatogr B Analyt Technol Biomed Life Sci. 2020, 1137. 

  6. Co-author for the “2019 White Paper on Recent Issues in Bioanalysis: FDA BMV Guidance, ICH M10 BMV Guideline and Regulatory Inputs (Part 2 - Recommendations on 2018 FDA BMV Guidance, 2019 ICH M10 BMV Draft Guideline and Regulatory Agencies' Input on Bioanalysis, Biomarkers and Immunogenicity)”. Bioanalysis. 2019, 11(23), 2099-2132. 

  7. Li F, Cousineau C, Xing G, Raha N, Clemens S, Mofikoya M, Kim MY, Zhang JY. Development and validation of a quantitative ultra-performance LC® hydrophilic interaction liquid chromatography MS/MS method to measure fructose and sorbitol in human plasma. Bioanalysis. 2019, 11(5), 407-425. 

  8. Jingduan Chi; Fumin Li*; Rand Jenkins. Quantitative Determination of sub-pg/mL Level of Tiotropium Bromide in Human Plasma by 2D-UHPLC-MS/MS: Challenges and Solutions. Bioanalysis, 2016, 8(5), 385-395. 

  9. Li F*, Ewles M, Pelzer M, Brus T, Ledvina A, Gray N, Koupaei-Abyazani M, Blackburn M. Case Studies: The Impact of Non-Analyte Components on LC-MS/MS Based Bioanalysis – Strategies for Identifying and Overcoming Matrix Effects. Bioanalysis, 2013, 5, 2409-2441.

  10. Li F*, Fast D, Michael S, Stephen, P.  Perforated dried blood spot accurate microsampling: the concept and its applications in toxicokinetic sample collection. Featured cover article in J. Mass Spectrom. 2012, 47, 655-667. 

  11. Li F, Fast D, Michael S. Absolute quantitation of protein therapeutics in biological matrices by enzymatic digestion and LC-MS. Bioanalysis. 2011; 3(21), 2459-80. 

  12. Li F*, Fast D, Michael S.  Absolute Quantitation of Protein Therapeutics in Biological Matrices by Enzymatic Digestion and Liquid Chromatography Tandem Mass Spectrometry. Bioanalysis, 2011, 3:2459-2480. 

  13. Li F*, Zulkoski J, Ding J, Brown W, Addison T.  LC-MS/MS Sensitivity Enhancement via Online Sample Dilution and Trapping: Applications in Microdosing and Dried Blood Spot (DBS) Bioanalysis.Rapid Commun. Mass Spectrom. 2010, 24: 2575-2583.  

  14. Li F. M.*; Schmerberg C. M.; Ji, Q. C. Accelerated Tryptic Digestion of Proteins in Plasma for Absolute Quantitation Using a Protein Internal Standard by LC-MS/MS. Rapid Commun. Mass Spectrom. 2009, 23: 729-732. 

  15. Tang, K. Q.; Li, F. M.; Shvartsburg, A. A.; Smith, R. D. Two-dimensional gas-phase separations coupled to mass spectrometry for analyses of complex mixtures. Anal. Chem. 2005, 77, 6381-6388. 

  16. Li, F. M.; Armstrong, D. W.; Houk, R. S. The behavior of bacteria in the inductively coupled plasma: Atomization and production of atomic ions for mass spectrometry. Anal. Chem. 2005, 77, 1407-1413. 

PRESENTATIONS (9 out of 65) 

  1.  Fumin Li. ICH M10: Interpretation and Comparison with Current Guidance on Bioanalytical Method Validation and Sample Analysis. An invited oral presentation at the Nanjing International DMPK Symposium, Dec 16 – 18, 2022.

  2. Fumin Li. Bioanalysis of Small Molecule Biomarkers. An invited oral presentation at the Nanjing International DMPK Symposium, Dec 16-18, 2022.   

  3. Trevor Zimmerman; Jinlin Shen; Guoyan Xu; Moucun Yuan; Dennis Kraus; William R. Mylott Jr; Fumin Li. Bioanalysis of Small Molecule and Biologics Drugs in Whole Blood Samples Collected in Mitra® - a Microsampling Device. A poster presented at 70th ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, USA, June 4 – 9, 2022.   

  4. Noah Post, Dennis Kraus, Ivy Smith, Eric Tewalt, Sarah Greenlee, John Matson, and Fumin Li. Quantitation of a GalNAc-Conjugated Antisense Oligonucleotide (ASO) and its Deconjugated Species via LC-MS/MS and hECL: A Comparison of Two Technologies.  A poster presented at 69th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, PA, USA, Oct 31 – Nov 4, 2021.   

  5. Dennis Kraus, Noah Post, Shannon Hall, Shabana Khan, and Fumin Li. Metabolite Profiling and Identification of an Antisense Oligonucleotide (ASO), Deconjugated ASOs, and Chain-Shorted ASOs from Human Plasma using IP-LC-UV-MS. A poster presented at 68th ASMS Conference on Mass Spectrometry and Allied Topics Reboot, June 1 – 12, 2020.   

  6. Jingduan Chi, Yonghua Ling, Shane Roller, and Fumin Li. Development and Validation of a LC-MS/MS Method for the Quantitation of Tenofovir Diphosphate in Dog PBMCs. A poster presented at 68th ASMS Conference on Mass Spectrometry and Allied Topics Reboot, June 1 – 12, 2020.   

  7. Ying Peng, Noah Post, Moo-young Kim, Shabana Khatri, Shannon Hall, and Fumin Li. Strategies for Bioanalysis of an Oligonucleotide and Chain-Shorted Metabolites from Human Plasma Employing LC-UV/MS/MS Detection. A poster presented at 67th ASMS Conference on Mass Spectrometry and Allied Topics, Atlanta, GA, USA, June 2 – 6, 2019. 

  8. Fumin Li, William Mylott, and Patrick Bennett. 2018 FDA BMV Guidance – PPD Interpretation & Implementation of New Requirement for “Small Molecules Endogenous Molecules/Biomarkers”: Case Studies & Discussion. An oral presentation at the 13th WRIB, April 1-5, 2019, New Orleans. 

  9. Ying Peng; Moo-Young Kim; Rand Jenkins; Fumin Li. Strategies to Improve Sensitivity and Reduce Carryover in Therapeutic Peptide Bioanalysis by LC-MS/MS: A Case Study of Liraglutide. A poster to be presented at 66th ASMS Conference on Mass Spectrometry and Allied Topics, San Diego, CA, USA, June 3 – 7, 2018. 

BOOK CHAPTERS

  1.  Fumin Li, a contributing author in the Bioanalysis Zone eBook: bioanalytical strategies for oligonucleotide assessment (bioanalysis-zone.com), 2021. 

  2. Fumin Li, Bruce Hidy and Rand Jenkins. “Sample Preparation in LC-MS Bioanalysis.” 2019, Wiley (ISBN:9781119274315). 

  3.  Dried blood spots: the future. Jack Henion, Regina V Oliveira, Fumin Li, Timothy P Foley, and Robert J Pomponio. In: Microsampling in Pharmaceutical Bioanalysis. Unitec House, 2 Albert Place, London N3 1QB, UK (Future Science Ltd) 2013. Pages 48-66 (eBook ISBN: 978-1-909453-58-6).   

  4. Fumin Li and Qin C. Ji. Liquid Chromatography Mass Spectrometry Bioanalysis of Protein Therapeutics and Biomarkers in Biological Matrices. Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications. 2011, Wiley.